… glycation of immunoreactive insulin (IRI) that was extracted from the pancreas of diabetic
animal … The spontaneously diabetic obese hyperglycemic (ob/ob) mouse displays many of the …

… The aim of this study was to exploit a novel, specific RIA (19) to measure glycated insulin
in two animal models of type 2 diabetes and to investigate the secretion of glycated insulin in …

… Degeneration of the islets of Langerhans with β-cell loss is secondary to insulin resistance …
Colonies of diabetes-prone and resistant animals have been selected according to their high-…

… HbA 1c was measured by using the glycated haemoglobin kit (Roche A/S, Hvidovre, Denmark).
HbA 1c and total Hb were measured from haemolysed blood and the percentage of HbA …

… in islets of Langerhans of non-diabetic animals (namely Han and AP Wistar, lean ZF and lean
ZDF rats) during islet … of glucose homeostasis due to insulin resistance and diabetes. The …

… of polyclonal antisera specific for glycated insulin and their usefulness in … glycated insulin
in plasma and islets of animal models of diabetes supports the view that glycation of insulin …

… diabetic conditions in vitro, such as high-glucose (HG) culture or AGE, or in vivo in animal
models of diabetes … cells (insulin-positive cells) as well as in non-beta cells (insulin-negative …

… for the separation and measurement of glycated and non-glycated insulin as described
above. In one experimental series, secretion of glycated insulin was … and diabetic animals. …

… Type II (non-insulin-dependent) diabetes mellitus is characterized by hyperglycemia… glycation,
which is a common posttranslational modification of human proteins especially in diabetes …